Minnesota has a diverse economy with strengths across many industry sectors. Part of this economic diversity comes from the state’s distinct regional economies. Each region possesses its own local advantages and specialized industries that contribute to the overall statewide economy. Yet, outcomes in the statewide economy can obscure trends and variations at the local and regional level. This article looks at how Minnesota’s economic regions performed over the first four years of the decade and assesses changes in each region’s key industry clusters.